Escalating antimicrobial resistance among Enterobacteriaceae: focus on carbapenemases

Introduction: Over the past few decades, antimicrobial resistance (AMR) has skyrocketed globally among bacteria within Family Enterobacteriaceae (i.e. Enterobacter spp, Klebsiella Escherichia coli, Proteus Serratia marcescens, Citrobacter and others). are intestinal flora important pathogens in nosocomial community settings. spread easily between humans may acquire AMR via plasmids or other mobile elements. The emergence of multidrug resistant (MDR) clones have greatly limited therapeutic options. Some infections untreatable with existing antimicrobials.Areas covered: authors discuss escalation CRE globally, epidemiology outcomes infections, optimal therapy, potential role several new antimicrobials to combat MDR organisms. An exhaustive search for literature related was performed using PubMed, following key words: resistance; carbapenemases; Enterobacterales; Enterobacteriaceae; pneumoniae; coli; global epidemiology; metallo-?-lactamases; New Delhi Metalloproteinase-1 (NDM-1); plasmidsExpert opinion: Innovation development classes antibacterial agents critical expand effective encourage judicious use antibiotics aggressive infection-control measures essential minimize AMR.